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Elucidating the precise pharmacological mechanism of action (MOA) of naturally developing compounds is often tough. Although Tarselli et al. (60) developed the first de novo artificial pathway to conolidine and showcased this naturally developing compound efficiently suppresses responses to each chemically induced and inflammation-derived pain, the

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" To date, the compound has demonstrated remarkably couple of, if any, Unwanted side effects, but that is one thing of the double-edged sword. "The dearth of Unintended effects can make it a very good applicant for enhancement," Bohn reported. "On the other hand, if there have been Uncomfortable side effects, they may offer additional clues concern